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  • Title: [Effects of oral contraceptives of cancerogenesis of cervical epithelium (author's transl)].
    Author: Soost HJ, Joswig-Priewe H.
    Journal: Arch Geschwulstforsch; 1978; 48(4):345-55. PubMed ID: 697547.
    Abstract:
    The question of hormonal action of oral ovulation inhibitor is discussed by means of publications up to the present. Some authors described endocervical hyperplasia, most of these informations were casuistic articles. Without doubt these lesions are benign. Cytophotometric measures of cervix cells of women using oral contraceptive steroids during a long time demonstrate quite normal DNA levels. Statistical comparisons between different groups, based on cytological and partially histological examinations, showed after using different oral contraceptive steroids preponderant high rates or sometimes lower rates of cervical atypia. Only a few examinations showed in comparison to a control gorup higher rate of dysplasia and carcinoma situ of the cervix. These results also were prevalance rates and no incidence rates. The difficulty of critical examination of statistical results is to consider that besides the normal effects of contraceptives many other factors have influence on cancerogenesis of the cervix. Most of all change of sexual behavior may be an important factor. The increased occurrence of cervical atypia as a direct effect of contraceptives could not yet be demonstrated.
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