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  • Title: Kartagener's syndrome. Preliminary report on cilia structure, function, and upper airway symptoms.
    Author: Pedersen M, Morkassel E, Nielsen MH, Mygind N.
    Journal: Chest; 1981 Dec; 80(6 Suppl):858-60. PubMed ID: 6975704.
    Abstract:
    Our study was designed to examine the motility and ultrastructure of cilia from the nose of patients with Kartagener's syndrome. Microphoto-oscillographic recording from single cells showed that the patients had in fact motile cilia, although the number was reduced. Asynchrony within the single cell was a more consistent feature. The first results of blind, quantitative microscopy showed the ultrastructural defects, described earlier, but the overlapping with a normal control group was considerable. Only one of nine patients had no dynein arms and completely immotile cilia; an observation which renders the term "the immotile-cilia syndrome" a misnomer. The ear-nose-throat symptoms were characterized by daily nose-blowings since birth, recurrent sinusitis, and chronic secretory otitis media. On the other hand, the frequency of acute purulent otitis media and of common colds appeared to be normal.
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