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  • Title: Synthetic C3a analogs as specific inhibitors of C3a activity.
    Author: Meuer S, Hadding U, Andreatta R, Bitter-Suermann D.
    Journal: Immunopharmacology; 1981 Sep; 3(3):275-80. PubMed ID: 6975766.
    Abstract:
    Various C3a-related C-terminal synthetic oligopeptides were investigated for their ability to induce a release of serotonin from guinea pig platelets. The results confirm earlier findings that expression of biological C3a activity requires the four to five C-terminal amino acids of the C3a primary structure and underlines the essential role of the C-terminal arginine. Besides their ability to induce a specific release reaction, these peptides--after short incubation with the platelets--lead to a specific desensitization of the cells for C3a or C3a-related stimuli. Expression of this inhibitory activity required concentrations of the peptides more than 100-fold lower than those that were necessary to induce secretion. The possibility of using C3a analogs as specific inhibitors for C3a offers a valuable tool for in vivo studies of biological C3a activity.
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