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  • Title: Heterogeneity of HLA-DR4 in the rheumatoid arthritis of a Chippewa band.
    Author: Harvey J, Arnett FC, Bias WB, Hsu SH, Stevens MB.
    Journal: J Rheumatol; 1981; 8(5):797-803. PubMed ID: 6975825.
    Abstract:
    A high frequency of both rheumatoid arthritis (RA) and HLA-DR4 was found in a Chippewa Indian population. Multiple immunogenetic "variants" of HLA-DR4 were demonstrated, each showing a different response in mixed lymphocyte culture which corresponded to a serologic pattern of reactivity to a panel of non-DR4 B cell alloantisera. No DR4-bearing HLA haplotype or DR4 "variant" was common to subjects with RA, all of whom were DR4-positive. The implications are discussed.
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