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  • Title: Effect of Fusarium toxins, T2-toxin and diacetoxyscirpenol on murine T-independent immune responses.
    Author: Rosenstein Y, Kretschmer RR, Lafarge-Frayssinet C.
    Journal: Immunology; 1981 Nov; 44(3):555-60. PubMed ID: 6976308.
    Abstract:
    Trichothecenes mycotoxins, T2-toxin and diacetoxyscirpenol were investigated for their effect upon T-independent murine immune responses. Both anti-polyvinylpyrrolidone and anti-dinitrophenylficoll responses were enhanced by chronic administration of these toxins. Spleen cells from T2-toxin-treated animals revealed significantly less Thy 1.2+ cells than controls. Spleen cells from Fusarium crude extract-treated animals had a depressed response to phytohaemagglutinin (PHA) as compared with controls. Normal recipients given spleen cells from T2-toxin-treated mice were shown to generate approximately 50% less plaque-forming cells against sheep red blood cells than controls. It is suggested that these effects occur as a result of altered T suppressor-cell function.
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