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  • Title: Adjuvant chemotherapy of soft-part sarcomas with ALOMAD (S4).
    Author: Sordillo PP, Magill GB, Shiu MH, Lesser M, Hajdu SI, Golbey RB.
    Journal: J Surg Oncol; 1981; 18(4):345-53. PubMed ID: 6976488.
    Abstract:
    Sixty-four adult patients with soft-tissue sarcomas received adjuvant chemotherapy with a six-drug combination regimen after surgery. Seventy percent remain free of disease with a median follow-up of 50 months. Only seven patients have died of their disease, all within the first 24 months after surgery. Most patients experienced severe nausea and vomiting secondary to the actinomycin D and dacarbazine parts of the protocol, and three patients experienced frank Adriamycin cardiomyopathy. Toxicity from this combination was otherwise mild. The 58% recurrence rate of 12 patients who discontinued therapy early because of nausea was significantly greater than the 23% rate for those who completed or relapsed on therapy (P = 0.01). Adjuvant chemotherapy should be considered after surgery for patients with soft-part sarcomas, especially those with high-grade tumors that have a considerable risk of recurrence.
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