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  • Title: Pharmacology of 8-aminoquinolines.
    Author: Grewal RS.
    Journal: Bull World Health Organ; 1981; 59(3):397-406. PubMed ID: 6976847.
    Abstract:
    The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective. This article reviews knowledge on the activity of these 8-aminoquinolines against all stages of the malaria parasite and suggests their possible modes of action. The toxic effects and possible causal mechanisms are also outlined.
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