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  • Title: Research on heterocyclic compounds. XII - Preparation and antiinflammatory activity of 2-methylimidazo [1,2-a]pyridine-3-carboxylic acids.
    Author: Abignente E, Arena F, De Caprariis P, Luraschi E, Marmo E, Lampa E, Vairo G, Somma A.
    Journal: Farmaco Sci; 1982 Jan; 37(1):22-35. PubMed ID: 6976907.
    Abstract:
    The synthesis of a series of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acids was accomplished by reacting some 2-aminopyridines with ethyl 2-chloroacetoacetate and then hydrolyzing the resulting ethyl carboxylates. Such new carboxylic acids were evaluated for antiinflammatory, analgesic, antipyretic, and ulcerogenic activities.
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