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  • Title: In vitro studies of 5, 10-methylenetetrahydrofolate reductase: inhibition by folate derivatives, folate antagonists, and monoamine derivatives.
    Author: Hollinger JL, Hommes OR, van de Wiel TJ, Kok JC, Jansen MJ.
    Journal: J Neurochem; 1982 Mar; 38(3):638-42. PubMed ID: 6977016.
    Abstract:
    Folate monoglutamates and folate antagonists have an inhibitory action on the activity of 5,10-methylenetetrahydrofolate reductase in rat brain. The type of inhibition was studied for dihydrofolic acid using the Lineweaver--Burk transformation. Some of the monoamine alkaloids, the in vitro products of 5,10-methylenetetrahydrofolate reductase, have either a stimulatory or inhibitory effect on the enzyme activity.
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