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  • Title: Human interleukin 2: production by both TG cells and other T cells.
    Author: Silva AG, Alvarez JM, Bonnard GD, de Landazuri MO.
    Journal: Scand J Immunol; 1981 Sep; 14(3):315-20. PubMed ID: 6977180.
    Abstract:
    We have investigated the production of interleukin 2 (IL-2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL-2. Further separation of rosette-forming cells, according to the expression of Fc receptors for IgG, showed that TG and non-TG cells are equally able to produce IL-2. The release of IL-2 by TG cells did not require DNA synthesis or functional Rc gamma receptors, since positively selected TH cells produced IL-2, even though they lacked lymphoproliferative responses to PHA and antibody-dependent cell-mediated cytotoxicity.
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