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  • Title: Synthesis and biological properties of some 5-aminoorotic acid derivatives.
    Author: Machoń Z, Jasztold-Howorko R.
    Journal: Pol J Pharmacol Pharm; 1981; 33(5):545-52. PubMed ID: 6977766.
    Abstract:
    2,4-Dihydroxy-5-benzoylaminopyrimidine-6-carboxylic acid 1 in the reaction with SOCI2 gave 1-benzoyl-2-oxo-4,6-dihyroxyazetino [3.2-d] pyrimidine 2 which reacted with aliphatic and aromatic amines in ethanol to give appropriate amides 4a-4h of 1 and ethyl 2,4-dihydroxy-5-benzolaminopyrimidine-6-carboxylate 5. Compounds 4d-4g and 8 were centrally active and showed a promising anti-inflammatory and analgesic activity.
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