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  • Title: Antigen-presenting properties of human vascular endothelial cells: inhibition by anti-HLA-DR antisera.
    Author: Hirschberg H, Hirschberg T, Jaffe E, Thornsby E.
    Journal: Scand J Immunol; 1981 Nov; 14(5):545-53. PubMed ID: 6977827.
    Abstract:
    Human vascular endothelial cells (EC) separated from the umbilical vein are capable of presenting antigen to in-vivo-sensitized T cells, leading to an immunoproliferative response to various antigens in vitro. Optimal T-cell response was only observed when the EC donor shared both HLA-D/DR determinants with the T-cell donor. The T-cell response normally observed when using antigen-pulsed EC was significantly and specifically inhibited by xeno- and allo-antisera reacting with the HLA-DR molecules. Moreover, antibodies reacting with the native antigen determinats (rubella virus) also appeared capable of inhibiting the response elicited by primed T cells to antigen-pulsed EC.
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