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  • Title: Brain target sites for 1,25-dihydroxyvitamin D3.
    Author: Stumpf WE, Sar M, Clark SA, DeLuca HF.
    Journal: Science; 1982 Mar 12; 215(4538):1403-5. PubMed ID: 6977846.
    Abstract:
    Autoradiographic studies with 3H-labeled 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] demonstrate, in certain neurons of rat forebrain, hindbrain, and spinal cord, a nuclear retention and concentration of radioactivity, which can be prevented by treatment with 1,25(OH)2D3, but not with 25-hydroxyvitamin D3. These results indicate the presence of brain receptors in addition to pituitary receptors for 1,25(OH)2D3 and suggest a central modulation of calcium homeostasis and other central effects for this hormone. The existence of a brain-pituitary axis for certain 1,25(OH)2D3-mediated endocrine-autonomic effects is postulated.
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