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  • Title: [Percentage of lymphocytes carrying receptors to complement 3 (EAC-RFC) and to Fc-fragment of IgG (Tgamma-lymphocytes) in the thymus and spleen of human fetus].
    Author: Riabchikov OP.
    Journal: Biull Eksp Biol Med; 1982 Jan; 93(1):50-2. PubMed ID: 6978159.
    Abstract:
    Adequate procedures were used to study the percentage of EAC-RFC and T gamma-cells in the thymus and spleen of 22 human fetuses aged 11-28 weeks obtained as a result of spontaneous abortions. It was established that the content of EAC-RFC in the thymus of the fetuses examined does not exceed 1% on the average in all periods of the ontogenesis, which corresponds with the number of Ig+-cells in the organ. The content of T gamma-cells in the spleen of the fetuses obtained in the course of spontaneous abortions ranges within from 1% on the average (weeks 11-14 of the ontogenesis) to 5.6% (weeks 24-28 of the prenatal ontogenesis). This number is far less as compared to that of such cells in the spleens of adult man (45%) and fetuses obtained as a result of criminal abortions (18-31%). It is suggested that the decreased number of T gamma-cells may play a role in the pathogenesis of spontaneous abortions and miscarriages.
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