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  • Title: Mutational enzymatic resistance of Enterobacter species to beta-lactam antibiotics.
    Author: Lampe MF, Allan BJ, Minshew BH, Sherris JC.
    Journal: Antimicrob Agents Chemother; 1982 Apr; 21(4):655-60. PubMed ID: 6979311.
    Abstract:
    Mutants with enhanced beta-lactam resistance were selected from strains of Enterobacter cloacae and E. aerogenes by using three antibiotics. High-level beta-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pI) values irrespective of the selective agent. Reverse mutants from a resistant E. cloacae mutant regained the susceptibility pattern originally exhibited by the wild type, or were of enhanced susceptibility, and no longer expressed increased beta-lactamase production. beta-Lactamases of the mutants were similar in pI values to the wild-type enzyme. The increased resistance of the mutants therefore appeared to be accounted for by increased beta-lactamase production.
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