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  • Title: Effect of C-reactive protein on granulocyte-macrophage progenitor cells.
    Author: Marcelletti JF, Johnson CS, Mortensen RF, Furmanski P.
    Journal: J Lab Clin Med; 1982 Jul; 100(1):70-80. PubMed ID: 6979594.
    Abstract:
    Pathophysiological concentrations of CRP inhibited the in vitro clonal proliferation of CFU-C's. CRP inhibition was specific for normal CFU-C's committed to the mononuclear phagocyte lineage. Macrophage progenitor cells stimulated by an inflammatory response were unaffected by CRP. CFU-C's which were committed to the granulocyte lineage, those which gave rise to both macrophages and granulocytes, and erythroid progenitor cells were also not affected by CRP. Only macrophage CFU-C's that possessed Fc receptors and were in S-phase at the time at CRP exposure were susceptible to inhibition of colony formation. The data suggest that CRP functions as a regulator of the cellular composition of an inflammatory response.
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