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  • Title: The inhibition of bacterial beta-lactamases by some monocyclic beta-lactams.
    Author: Isaacs NS, Sunman G, Reading C.
    Journal: J Antibiot (Tokyo); 1982 May; 35(5):589-93. PubMed ID: 6980873.
    Abstract:
    The inhibition characteristics of 25 monocyclic beta-lactams mainly with an amido function at C3 have been studied against the beta-lactamases produced by 4 bacterial types. Significant levels of inhibition were found for only a few of the compounds tested and primarily against Staphylococcus beta-lactamase. The most active inhibitor tested, 3-p-nitrophenylacetamido-4-phenylazetidin-2-one, was found to require a cis geometry, the trans isomer being almost inactive.
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