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  • Title: Neonatal suppression with anti-Ia antibody. I. Suppression of murine B lymphocyte development.
    Author: Fultz MJ, Scher I, Finkelman FD, Kincade P, Mond JJ.
    Journal: J Immunol; 1982 Sep; 129(3):992-5. PubMed ID: 6980929.
    Abstract:
    To investigate the role of sIa in B lymphocyte development, mice were injected from birth with hybridoma anti-Ia antibody. There was on the average a 95% reduction in the number of sIgD+ cells, and 85% diminution in the number of sIgM+ cells, a small but significant increase in the number of sIgM+ sIgD- sla- B cells, as well as a dramatic increase in the number of sIgM- cells bearing a B lineage antigen. Exposure of cells to high doses of anti-Ia antibody in vitro or in vivo for 24 hr did not affect the number of sIg+ lymphocytes. Thus, it appears that chronic anti-Ia administration critically alters normal B lymphocyte development.
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