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  • Title: Testicular in vitro conversion of progesterone to testosterone and androstenedione in 17 alpha-hydroxylase deficiency.
    Author: Salti IS, Hajj H, Dhib-Jalbut S.
    Journal: J Steroid Biochem; 1982 Aug; 17(2):155-7. PubMed ID: 6981031.
    Abstract:
    Incubations of [3H]-progesterone with testicular tissue obtained from a new case of male with 17 alpha-hydroxylase deficiency were performed. The per cent conversion to androstenedione and testosterone was virtually absent when compared to that obtained from an identical incubation performed using testicular tissue from a normal male with cryptochordism. The findings provide an in vitro evidence in support of the existence of 17 alpha-hydroxylase testicular defect in this disorder.
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