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  • Title: Studies on autoantibodies to poly (adenosine diphosphate-ribose) in SLE and other autoimmune diseases.
    Author: Morrow WJ, Isenberg DA, Parry HF, Shen L, Okolie EE, Farzaneh F, Shall S, Snaith ML.
    Journal: Ann Rheum Dis; 1982 Aug; 41(4):396-402. PubMed ID: 6981386.
    Abstract:
    Sera from 41 patients with systemic lupus erythematosus (SLE), 87 controls with various diseases, and 30 normal subjects were examined for poly (adenosine diphosphate-ribose) and ds DNA binding. Elevated levels of poly (ADP-ribose) binding were found in 73% of the SLE patients compared with 58% who had raised ds DNA binding. In a further study of 160 sera from 27 patients with SLE, levels of antipoly (ADP-ribose) antibodies were shown to correlate with clinical activity better than either anti-ds DNA or ss DNA antibodies.
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