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  • Title: In vitro activity and beta-lactamase stability of N-formimidoyl thienamycin compared to that of second and third generation cephalosporins.
    Author: Vuye A.
    Journal: Chemotherapy; 1982; 28(4):267-75. PubMed ID: 6981493.
    Abstract:
    N-Formimidoyl thienamycin (MK0787) was found to be active against 21 gram-negative isolates, selected for their beta-lactamase production. None of the crude beta-lactamases could hydrolyze MK0787 or cefoxitin, in contrast to cefotaxime which was moderately attacked by a number of enzymes. MK0787 behaved as a moderate inhibitor of most beta-lactamases, whereas cefoxitin and cefotaxime were strong inhibitors of cephalosporinases but not of broad-spectrum enzymes. The new compound had good penetration characteristics in a strain of Enterobacter cloacae, in contrast to cefoxitin. Against a number of trained cefamandole- and cefoxitin-resistant variants, MK0787 was clearly the most active of the compounds tested.
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