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  • Title: Chronic lymphocytic leukemia: a monoclonal disease.
    Author: Solanki DL, McCurdy PR, MacDermott RP.
    Journal: Am J Hematol; 1982 Sep; 13(2):159-62. PubMed ID: 6982616.
    Abstract:
    A black woman with chronic lymphocytic leukemia (CLL) was found to have monoclonal B lymphocytes with one type of surface immunoglobulin and one variant of G6PD (glucose-6-phosphate dehydrogenase) (G6PD A). Erythrocytes and T cells contained both G6PD A and G6PD B and hence were of polyclonal origin. The CLL cells in this patient likely arose from a developmental stage later than the step of differentiation into T and B lymphocytes. Furthermore, her erythrocytes did not arise from a stem cell affected by the CLL process.
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