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  • Title: The interaction of anthraquinone dyes with the plasmid-mediated OXA-2 beta-lactamase.
    Author: Monaghan C, Holland S, Dale JW.
    Journal: Biochem J; 1982 Aug 01; 205(2):413-7. PubMed ID: 6982708.
    Abstract:
    Although beta-lactamases do not require any nucleotide co-substrates, the OXA-2 type is inhibited competitively by Cibacron Blue 3GA, and by other anthraquinone dyes, including some simpler compounds with no side chain. The enzyme causes a red shift in the spectrum of Cibacron Blue. The beta-lactamase can be adsorbed in Blue Sepharose and specifically eluted by benzylpenicillin. These results indicate that the binding of anthraquinone dyes is a specific effect similar to that seen with many nucleotide-binding enzymes.
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