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  • Title: B cell growth factor and T cell growth factor produced by mitogen-stimulated normal human peripheral blood T lymphocytes are distinct molecules.
    Author: Muraguchi A, Kasahara T, Oppenheim JJ, Fauci AS.
    Journal: J Immunol; 1982 Dec; 129(6):2486-9. PubMed ID: 6982927.
    Abstract:
    Using a recently described assay for inducing and measuring the proliferation of normal human B cells in the absence of differentiation, we have demonstrated that B cell growth factor (BCGF) activity can be obtained from the culture of human peripheral blood mononuclear cells in the presence of mitogens. Using Sephacryl S-200 gel filtration, BCGF activity was demonstrated in the 20 to 30K m.w. fractions of mitogen-stimulated peripheral blood mononuclear cells. However, this fraction also showed substantial T cell growth factor (TCGF) activity. Despite this overlapping of m.w., BCGF activity could clearly be separated from TCGF activity by selective absorption of factor-containing supernatants with the interleukin 2 activity by using interleukin 2-dependent cells without any diminution of BCGF activity, strongly suggesting that these two factors may be distinct molecular entities.
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