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  • Title: T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.
    Author: Albertini RJ, Castle KL, Borcherding WR.
    Journal: Proc Natl Acad Sci U S A; 1982 Nov; 79(21):6617-21. PubMed ID: 6983072.
    Abstract:
    Rare thioguanine-resistant T lymphocytes, present in vivo in human peripheral blood, were isolated and grown in vitro as thioguanine-resistant cultured T cells. The conditions for their selection in vitro were such that thioguanine resistance had to have arisen in vivo. The mutant cells bore T-cell surface markers, maintained their thioguanine resistance in vitro in the presence or absence of selection, and were deficient in hypoxanthine-guanine phosphoribosyltransferase activity.
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