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  • Title: Serum immunoglobulins in minimal change nephrotic syndrome--a possible defect in T-cell function.
    Author: Rashid H, Skillen AW, Morley AR, Kerr DN.
    Journal: Bangladesh Med Res Counc Bull; 1982 Jun; 8(1):15-20. PubMed ID: 6983346.
    Abstract:
    Serum immunoglobulin concentrations were determined in eighteen patients with minimal change nephrotic syndrome. Serum IgG and IgA were significantly decreased; whereas IgM was significantly increased in majority of the cases. Eight of the eighteen patients were treated with steroids. All the eight patients showed a significant increase in serum IgG and a decrease in IgM in response to steroid therapy. The increased serum IgM and decreased IgG before treatment and their restoration to normal levels after steroid therapy may suggest a possible defect in T-cell function.
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