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  • Title: Hydroxyurea increases in vitro, antigen-independent B cell development in bone marrow.
    Author: Le Bouteiller PP, Ashersn GL, Edwards AJ.
    Journal: Clin Exp Immunol; 1982 Sep; 49(3):695-700. PubMed ID: 6983405.
    Abstract:
    The fluorescence-activated cell sorter and Coulter counter were used to study the effect of hydroxyurea in vitro in B cell development in 24 hr cultures of adult mouse bone marrow. This agent, which kills cells in the S phase of the cell cycle, caused a 40-70% increase in the absolute number of B cells in bone marrow cultures as compared with untreated cultures. There was also an increased response to the B cell mitogen, bacterial lipopolysaccharide, as measured by the stimulation index for 3H-thymidine incorporation. Hydroxyurea in vitro increased B cells numbers in fetal liver which contains pre-B cells, but not in lymph nodes or spleen which lack these cells.
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