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Title: [Decreased sensitivity of frog bladder cells to the antidiuretic hormone in the presence of D20]. Author: Shakhmatova EI, Natochin IuV, Petrov LN. Journal: Probl Endokrinol (Mosk); 1982; 28(6):71-4. PubMed ID: 6984184. Abstract: Antidiuretic hormone (ADH) does not enhance the bladder wall permeability for the water, when 50% of the water is substituted for D2O in Ringer's solution. ADH reaction is partially reduced in the inhibition of phosphodiesterase activity by theophylline. In D2O presence cAMP-theophylline combination stimulates the water penetration, growing in proportion to an increase in Ringer's solution osmolarity under polyethylene glycol 400 action. It is suggested that D2O affects ADH-membrane receptor interaction or intensifies cAMP destruction, but the effectiveness of the subsequent intracellular reactions, stipulating augmentation of osmotic permeability, persists.[Abstract] [Full Text] [Related] [New Search]