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  • Title: Cimetidine does not stimulate human T lymphocyte functions in vitro.
    Author: Charpentier B, Lang P, Martin B, Fries D.
    Journal: Biomed Pharmacother; 1982; 36(5):250-4. PubMed ID: 6984826.
    Abstract:
    Cimetidine, an H2-receptor antagonist had no immunoproliferative or immunostimulative effect on in vitro T cell functions of normal human peripheral blood lymphocytes. This was shown by adding Cimetidine to mitogen, alloantigen and xenoantigen-stimulated cultures. Generation of helper and cytotoxic T cells was not modified in a full kinetic experiment. These data failed to confirm previous reports showing an increase of cell-mediated immunity under Cimetidine therapy.
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