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  • Title: Purification and immunohistochemical localization of rat liver glutathione peroxidase.
    Author: Yoshimura S, Komatsu N, Watanabe K.
    Journal: Biochim Biophys Acta; 1980 Jan 24; 621(1):130-7. PubMed ID: 6986175.
    Abstract:
    Glutathione peroxidase was purified from the rat liver to give a single protein band in polyacrylamide gel electrophoresis. Rabbits were immunized with this purified enzyme, and a highly specific anti-glutathione peroxidase antiserum was obtained. Using this antibody, an immunohistochemical technique (the indirect method of peroxidase-labeled antibody) was applied to study the localization of the enzyme in the liver cells. On immunohistochemical observation, glutathione peroxidase was localized exclusively in the cytoplasm of hepatocytes, and a stronger 'immuno-staining' was exhibited in the peripheries of the hepatic lobules than in the central zone.
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