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  • Title: Influence of the age of erythrocytes on their insulin receptors.
    Author: Eng J, Lee L, Yalow RS.
    Journal: Diabetes; 1980 Feb; 29(2):164-6. PubMed ID: 6986304.
    Abstract:
    Specific binding of 125I-insulin to erythrocyte receptors increased linearly with reticulocyte count in routine blood specimens from hospitalized patients. Specific binding as high as 30-35% is observed in patients with reticulocyte counts in the range of 20-25% compared with 9.0 +/- 0.5% specific binding in healthy control subjects with normal reticulocyte counts. It is concluded that care must be exercised in interpreting elevations of specific 125I-insulin binding to erythrocyte receptors as due to specific disease processes without considering how the disease itself may alter mean erythrocyte age at the time of sampling.
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