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  • Title: alpha-Lactalbumin-casein induction in virgin mouse mammary explants: dose-dependent differential action of cortisol.
    Author: Ono M, Oka T.
    Journal: Science; 1980 Mar 21; 207(4437):1367-9. PubMed ID: 6986657.
    Abstract:
    The interplay of insulin, cortisol, and prolactin induces synthesis of casein and alpha-lactalbumin in cultured mammary explants from mature virgin mice. A striking difference has been found between the optimal concentrations of cortisol required for maximal induction of the two milk proteins in vitro: 3 x 10(-8) molar for alpha-lactalbumin and 3 x 10(-6) molar for casein. Moreover, 10(-7) to 10(-5) molar cortisol caused progressive inhibition of alpha-lactalbumin accumulation. Such differential actions of cortisol may partly account for the asynchronous synthesis of the two proteins during pregnancy.
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