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  • Title: Combination antibiotic therapy of bacterial endocarditis.
    Author: Sande MA, Scheld WM.
    Journal: Ann Intern Med; 1980 Mar; 92(3):390-5. PubMed ID: 6986829.
    Abstract:
    A penicillin-aminoglycoside regimen is accepted therapy for enterococcal endocarditis, but use of combinations of antibiotics in other forms of bacterial endocarditis is controversial. This review analyzes in-vitro, experimental animal model, and clinical studies of combination "synergistic" antibiotic treatment for enterococcal, viridans streptococcal, staphylococcal, and gram-negative aerobic bacillary endocarditis. Current recommendations for treatment of these entities are discussed.
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