These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of endotoxin treatment on prostaglandin metabolism by rabbit uterus and oviduct.
    Author: Harper MJ, Bodkhe RR, Friedrichs WE.
    Journal: J Reprod Fertil; 1980 Jan; 58(1):101-8. PubMed ID: 6987394.
    Abstract:
    Metabolism of PGE-2 and PGF-2 alpha by cytosolic fractions (100,000 g supernatant) of the uterus, oviduct and lung of rabbits treated with hCG and endotoxin (20 microgram/kg) was measured. Endotoxin caused immediate decreases in metabolism of both PGs by uterus at 1 h, and these decreases became significant at 2 h for PGE-2 and 6 h for PGF-2 alpha. The metabolism of both PGs remained depressed throughout the 24 h study. Metabolism by oviduct tissue differed in that at 1 h metabolism of both PGs increased but then remained depressed between 2 and 24 h. Metabolism of PGs by lung also showed a different pattern: that of PGE-2 was depressed only briefly (at 2 h), while that of PGF-2 alpha was consistently depressed between 2 and 24 h. Pre-treatment with hCG did not affect the response: tissues from animals killed 6 h after endotoxin but not given hCT responded like those from animals treated with endotoxin 24 h after hCG and killed 6 h later. Much of the increased PG levels in venous drainage after endotoxin treatment can be explained by depressed ability of cells to metabolize PGs.
    [Abstract] [Full Text] [Related] [New Search]