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  • Title: Comparison of labetalol and propranolol in hypertension.
    Author: Nicholls DP, Husaini MH, Bulpitt CJ, Stephens MD, Butler AG.
    Journal: Br J Clin Pharmacol; 1980 Mar; 9(3):233-7. PubMed ID: 6988003.
    Abstract:
    1 Labetalol has been compared with propranolol in a double-blind, double-dummy study of 24 patients with mild or moderate essential hypertension. 2 Two patients were unable to tolerate propranolol and five labetalol, because of symptom side effects; this difference was not significant (P greater than 0.1). 3 On a self-administered questionnaire, labetalol was associated with a greater number of side effects per patient than propranolol, but no individual side effect was significantly more common with either drug. 4 There was no difference in the number of spontaneously reported side effects between the two drugs. 5 Both drugs impaired pulmonary function, but propranolol caused a greater reduction than labetalol after 8 weeks of treatment. 6 We conclude that labetalol and propranolol are similarly effective and acceptable to the patient.
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