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  • Title: Differential actions of the prostaglandins on the pulmonary vascular bed.
    Author: Kadowitz PJ, Spannhake EW, Levin JL, Hyman AL.
    Journal: Adv Prostaglandin Thromboxane Res; 1980; 7():731-43. PubMed ID: 6989201.
    Abstract:
    We have reported that administration of cyclooxygenase inhibitors such as indomethacin and meclofenamate results in a slow gradual increase in pulmonary vascular resistance in the intact dog (21). It has been shown that a PGI2, "like" substance is continually released by the lung (6). We have, therefore, suggested that under resting conditions, the pulmonary vascular bed is maintained in a dilated state by production of a vasodilator product in the cyclooxygenase pathway (10,21). Recent evidence suggests that this vasodilator product in the cyclooxygenase pathway is a PGI2 'like" substance (6,13,20).
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