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  • Title: Mitogenic and antigenic properties of group A streptococcal M protein preparations.
    Author: Knöll H, Kühnemund O, Havlícek J.
    Journal: Immunobiology; 1980 Jan; 156(4-5):537-48. PubMed ID: 6989752.
    Abstract:
    The separation of a mitogenic substance in M protein preparations of Streptococcus pyogenes, type 1 and type 12, is described. The isolation was achieved by gel chromatography on Biogel A 0.5 m, and by immunochromatography on immobilized type specific antibodies. In the delayed cutaneous hypersensitivity test the immunochromatography purified M 1 protein caused erythema but no unspecific mitogenicity could be found by lymphocyte transformation test. In neutralization experiments the mitogenic activity of M protein preparations was specifically inhibited by anti-erythrogenic toxin antisera.
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