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  • Title: [Comparative morphological and insulin-producing characteristics of cellular cultures of the islands of Langerhans in experimental animals].
    Author: Komissarenko VP, Turchin IS, Lazareva NP.
    Journal: Probl Endokrinol (Mosk); 1980; 26(2):85-9. PubMed ID: 6990405.
    Abstract:
    The pancreas from cattle and pigs (5--6-month-old), newborn rats, and guinea pits (1--1.5-month-old) was subjected to combined with trypsin and Wersen solutions and collagenase. Morphological changes and the insulin-producing activity of the primary cultures of the islet cells from these pancreas were studied. B- and A-cells were identified histologically. Concentration of insulin produced in the culture medium was determined immunoradiologically. The culture studied proved to preserve the morphological and functional differentiation for 4 to 5 weeks from the growth onset; their morphological changes during growth were similar. The level of the insulin produced depended on the cell composition and functional state of the culture. Increased glucse concentration (300 mg %) stimulated insulin secretion.
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