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  • Title: Evaluation of glycopyrrolate and atropine as adjuncts to reversal of non-depolarizing neuromuscular blocking agents in a "true-to-life" situation.
    Author: Cozanitis DA, Dundee JW, Merrett JD, Jones CJ, Mirakhur RK.
    Journal: Br J Anaesth; 1980 Jan; 52(1):85-9. PubMed ID: 6990948.
    Abstract:
    Glycopyrrolate, a quaternary ammonium anticholinergic compound, and atropine were evaluated in combination with neostigmine for antagonism of non-depolarizing neuromuscular block. A total of 641 patients were investigated in a "true-to-life" situation. The patients receiving glycopyrrolate with neostigmine had smaller changes in heart rate than those who received atropine. This was particularly apparent in patients with cardiovascular disease.
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