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  • Title: [Immunoglobulin-positive cells of the human spleen and thymus in embryogenesis].
    Author: Chuich NA.
    Journal: Biull Eksp Biol Med; 1980; 89(1):38-40. PubMed ID: 6991021.
    Abstract:
    The percentage and types of fluorescence of immunoglobulin-positive cells were studied in the spleen and thymus from 32 human fetuses aged from 11 to 32 weeks by indirect immunofluorescence. During embryogenesis the number of immunoglobulin-positive cells in the spleen rises from 13 to 33.7%, while in the thymus the percentage of these cells is 0--2 and does not depend on the period of the fetus development. Differentiated estimation of immunoglobulin-positive cells was performed for the first time during embryogenesis from the types of fluorescence. Thymocytes have solitary points of fluorescence on the surface. Lymphocytes with solitary and then with multiple points covering all the surface and at last with "caps" of fluorescence appear in the spleen during the period of the development. The different density of immunoglobulin receptors on the surface reflects the level of lymphocyte differentiation.
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