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  • Title: Disparate effects of enkephalin and morphine upon insulin and glucagon secretion by islet cell cultures.
    Author: Kanter RA, Ensinck JW, Fujimoto WY.
    Journal: Diabetes; 1980 Jan; 29(1):84-6. PubMed ID: 6991319.
    Abstract:
    Insulin and glucagon release from monolayer pancreatic islet cell cultures were inhibited in a dose-response fashion by various enkephalins. Morphine, however, stimulated insulin and glucagon release. Both effects were blocked by naloxone, while naloxone alone had no effect. In isolated and denervated islet cells, opiates directly influence secretion from islet cells.
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