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  • Title: [Insulin analogues with substitution of A1-glycine by D-amino acids and omega-amino acids (author's transl)].
    Author: Geiger R, Geisen K, Regitz G, Summ HD, Langner D.
    Journal: Hoppe Seylers Z Physiol Chem; 1980 Apr; 361(4):563-70. PubMed ID: 6991387.
    Abstract:
    Substitution of A1-glycine of insulin by L-amino acids yields in analogues with low biological activity. With D-amino acids in A1 biological activity is essentially retained. The influence of aliphatic, aromatic, acidic and basic alpha-D-amino acids as well as omega-amino acids in A1 on the biological effects in different test systems is studied and discussed.
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