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  • Title: Reversible suppression of allo-antibody production by cyclosporin A.
    Author: Denham S, Styles JM, Barfoot RK, Dean CJ.
    Journal: Int Arch Allergy Appl Immunol; 1980; 62(4):453-8. PubMed ID: 6991444.
    Abstract:
    Treatment of rats with 25 mg/kg/day of cyclosporin A suppressed their immune response to skin allografts. Withdrawal of cyclosporin A treatment led to complete recovery of specific immune responsiveness and the time taken for recovery was independent of the duration of treatment. Titration of the dose of cyclosporin A administered in vivo indicated that doses of 12 mg/kg/day or less were not fully immunosuppressive.
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