These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mutagenicity of several pancreatic carcinogenic derivatives of N-nitrosodipropylamine in the Ames assay.
    Author: Wislocki P, Gingell R.
    Journal: Mutat Res; 1980 Mar; 77(3):215-9. PubMed ID: 6991919.
    Abstract:
    The mutagenic activity of several N-nitrosamines related to the potent hamster pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) has been investigated using the Ames Salmonella/microsomal mutagenicity test system. S9 from the livers of phenobarbital-pretreated hamsters was the source of activating enzyme, and strain TA1530 was the indicator organism. Mutagenicity assays of BOP, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), N-nitroso-2,6-dimethylmorpholine (NDMM) and N-nitrosomorpholine (NM) indicate that only HPOP was strongly mutagenic in the absence of the hamster-liver preparation. In the presence of this activation system, NDMM was the most mutagenic, and cis NDMM was 2-3 times more mutagenic than the trans isomer of this compound. BOP and BHP were considerably less mutagenic than HPOP.
    [Abstract] [Full Text] [Related] [New Search]