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  • Title: Mutagenicity of nifurtimox in Escherichia coli.
    Author: Ohnishi T, Ohashi Y, Nozu K, Inoki S.
    Journal: Mutat Res; 1980 Mar; 77(3):241-4. PubMed ID: 6991921.
    Abstract:
    The effects of nifurtimox, a nitrofuran derivative, on killing and mutation induction in 3 Escherichia coli strains having different DNA-repair systems for UV lesion were studied and compared with the effects of furylfuramide. Nifurtimox induces mutations at a high frequency in both Hs3OR (uvrA-) and H/r30R (radiation-resistant), although no significant killing effect is detected with Hs30R. No significantly induced mutation frequency could be detected with NG30 (recA-), which is very sensitive to killing by nifurtimox. The characteristics of lesions of DNA induced by nifurtimox and the mechanism of mutation induction in Hs30R are discussed.
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