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  • Title: Conversions of prostaglandin endoperoxides by prostacyclin synthase from pig aorta.
    Author: Wlodawer P, Hammarström S.
    Journal: Prostaglandins; 1980 Jun; 19(6):969-76. PubMed ID: 6992239.
    Abstract:
    Partially purified prostacyclin synthase from pig aorta converted the prostaglandin (PG) endoperoxide PGH2 to prostacyclin (PGI2), and PGH1 to 12-hydroxy-8,10-heptadecadienoic acid (HHD). Both reactions were inhibited by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HP) in a dose-dependent rashion. However, the reactions PGH2 leads to PGI2 and PGH1 leads to HHD appeared to differ: substrate availability was rate limiting in the latter reaction, while the enzyme became rapidly saturated witth PGH2 and a steady rate of prostacyclin formation was observed at higher substrate levels.
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