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  • Title: Neighbour and temperature effects on base-analogue-induced mutation in phage T4.
    Author: Ronen A, Halevy C.
    Journal: Mol Gen Genet; 1980; 178(2):397-401. PubMed ID: 6993847.
    Abstract:
    The effects of neighbouring base pairs and of temperature on mutation frequencies were measured at nonsense sites in the T4rII region. 2AP-induced AT leads to GC transition frequencies are insensitive to nearest-neighbour effects, while 5BU-induced ones are promoted by GC neighbours on the 5' side. The effect of temperature on 2AP- and 5BU-induced mutation frequencies shows no simple dependence on nearest neighbours. These results are incompatible with a unitary mechanism as explanation for the effects of nearest neighbours and temperature on base-analogue-induced mutagenesis.
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