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  • Title: Antagonists of morphine-induced respiratory depression. A study in postoperative patients.
    Author: Gairola RL, Gupta PK, Pandley K.
    Journal: Anaesthesia; 1980 Jan; 35(1):17-21. PubMed ID: 6994518.
    Abstract:
    This double blind study showed the effect of four drugs, levallorphan, naloxone, doxapram and amiphenazole, an opiate-induced analgesia and respiratory depression. Satisfactory analgesia was induced by administration of morphine intravenously in a dose of up to 0.33 mg/kg; such a dose, however, produced significant depression of respiration. Administration of levallorphan, naloxone, and amiphenazole produced reversal of respiratory depression and analgesia. Doxapram reversed the respiratory depression but did not alter analgesia.
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