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  • Title: An ambulatory trial of guanfacine.
    Author: Mann S, Millar Craig MW, Melville DI, Cashman PM, Raftery EB.
    Journal: Br J Clin Pharmacol; 1980; 10 Suppl 1(Suppl 1):103S-107S. PubMed ID: 6994762.
    Abstract:
    1. The effects of acute and long-term treatment with guanfacine on ambulatory BP were studied. 2. The first day of therapy with guanfacine 1 mg produced a small reduction in BP whereas chronic therapy with doses up to 6 mg given once daily produced a substantial smooth reduction throughout the whole 24 hours. 3. There were no noticeable symptoms or rebound effects on withdrawal of the drug; side-effects, were, however, prominent during therapy. 4. The drug reduced BP during dynamic exercise but did little during isometric exercise; no postural hypotension was noted during tilting.
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