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  • Title: Once-daily dosing of timolol in hypertension: a controlled study.
    Author: Edwards IR, Else O.
    Journal: Eur J Clin Pharmacol; 1980 Apr; 17(4):239-41. PubMed ID: 6995126.
    Abstract:
    Nine previously untreated patients with mild-moderate hypertension were included in a dose-ranging double-blind trial to determine the effectiveness of daily versus thrice daily timolol administration. In 8 patients control of blood pressure was equally effective though with significantly lower heart rate achieved in the once daily group. One patient was not satisfactorily controlled on the daily regimen demostrating that many but not all hypertensives can be controlled with daily administration of timolol.
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